The Future of Education in US and Saudi Arabia Essay

The Future of Education in US and Saudi Arabia - Essay Example According to the research findings the revolution in the education sector will also result in an overall information symmetry to the residents of both countries and at large the world. The education infrastructure will also get upgraded and the funds spend on the acquisition teaching staff decline. It will become a cost cutting strategy as the education sector has over time utilized large amounts of capital that could have got utilized in developing other sectors. The overall adoption of technology in the education sector will eventually result in a declined rate of illiteracy and ignorance levels as learning shall become a progressive exercise.From the discussion it is clear that  the initiation of formal education dates back to the 19th century when people saw the need of adopting a formalized educational system as opposed to the informal. The future of the education will heavily relay on the adoption of formalized systems of impacting knowledge to the students. The development a genda of the education sector will heavily rely on the methods of overcoming the barriers that have for long hindered the development and establishment of formalized education in both US and Saudi Arabia. The aim is to ensure that learning can take place anyplace anytime so long as there learner has a willingness to learn. The idea of students going to school for classes shall change and become history. It is so as classroom learning will no longer be taking place and if it happens to be shall be made for the young generation only.

Grammy Nominees Essay Example | Topics and Well Written Essays - 500 words

Grammy Nominees - Essay Example The lyrics to this powerful melody are pleading, calming and contemplative. They are words the audience identifies with easily. The signature banjo beat adopted in the song gives it a developed alternative rock sound (Natasha, 1). The band remains true to their sound while capturing a wide fan base. The use of upbeat instruments creates hope for the rather sorrowful lyrics. This is especially appropriate as the song it titled, â€Å"I will wait†. Snoop Dog & Wiz Khalifa featuring Bruno Mars deliver â€Å"Young, Wild and Free† in a simplified manner that earns the song the top vote in the Rap category. The song contains one of the most catchy choruses of the year behind that of â€Å"We are Young† by Fun. Bruno Mars’ vocal infusion to the chorus softens the track. The collaborative effort between Wiz Khalifa and Snoop is blended, continuous and refined. The song is memorable beyond several hip hop songs. Miguel captures the attention of the world with his song â€Å"Adorn†. It gets the best R&B song as a result of its soulful feel. The song is intimate and sincere. The video delivers the songs most powerful elements alongside Miguel’s powerful voice. The song’s quality makes it a track that will remain relevant for several years to come. It elevates Miguel from an underdog R&B singer to a top performer. â€Å"Even if it Breaks your Heart† by Eli Young Band wins the Best Country Song. The track depicts the essence of optimism and resilience in failure. It is a great lesson for the audience. The track is well developed with great musical instruments and vocals. The winning point for the song is the poetic lyrics that pushes composition boundaries (Dukes, 1). The Best Gospel Song vote goes to Marvin Sapp with his song, â€Å"My Testimony†. It is an autobiographical account of the singer’s struggle with the death of his wife following a long battle with cancer. The song is soulful, hopeful and inspiring. The powerful lyrics captivate the listener

Social Historical Bacground Essay Example for Free

Social Historical Bacground Essay A Dolls House was first published in Copenhagen, Denmark in December 1879. The first edition of the play flew of the shelves with 8000 copies sold within the first month. The play was then staged at Copenhagens Royal Theatre on the 21st of December of the same year. This allowed people who had read the manuscript (men), as well as those people who could not read (women), the chance to see Ibsens visual representation of his play. Women were less likely to read as they were less likely to attend school. Therefore, when men and women attended theatres a difference of opinion arose. Women were for the independence of Nora whilst men found it scandalous. However, both genders found elements of the play scandalous such as the lack of a happy ending, a sign of naturalistic drama of which Ibsen was a master. Most other playwrights of the time were still writing plays which adhered to the conventions laid out by Ancient Greek tragedy: the play must be in verse and about people of high social status. A Dolls House featured simple prose and was about people of different statutory. The Royal Theatre was frequented by both people of high status and low status. This only scandalised audiences even more as the higher status audiences were disgusted whilst lower status audience members applauded Ibsen. A Dolls House was the centre of conversations in Copenhagen and soon news of the scandalous play travelled across Denmark and beyond. By the following year the play had reached audiences in Europe whilst by 1990 the play had appeared in most continents of the world. The shocking nature of the play meant that not all conversations related to A Dolls House were good. This can be seen in the array of critical commentary the play has received. Such commentary was fuelled by Ibsen when in 1898 he denounced that he wrote the play with the womens rights movement in mind: To me it has seemed a problem of mankind in general. Others believed this too, such as Zelda Fichandler working for the Washington Post who wrote: Womens rightsis too limited a subject to be the stuff of art. With the freedom of women now dismissed as Ibsens goal, critics began to draw up their own conclusions as to what the play was about. Michael Meyer wrote: Its theme is the need of every individual to find out the kind of person he or she really is and to strive to become that person. This comment is regarded in todays world as quite valid. Modern audiences can accept that Ibsens focus was not just on women, but that the play could be applied to both sexes. Meanwhile, audiences of the past could not accept this which lead to some alteration of the text and its production. The play was altered by directors and producers for two main reasons: either the producers were disturbed by its content or they were trying to stage the play in a new way. The ending of the play was changed in Germany when the actress cast as Nora said that she could never leave her children. Ibsen saw the changes as a barbaric outrage on the play but could not do anything due to the lack of copyright. The changing of the end brought about public outcry and the ending was reverted to its original. Another person to change the script because of children was Eleonora Duse but she changed the script as she found it difficult to bring child actors on tour from Italy. The play was also staged in several different ways. Meyerholds set of the play was changed from comfortable to cramped. He included rickety furniture with a long red drape hanging over the window to express his idea that everything was collapsing going to the devil. This view is, in my opinion, very true. It is not only Nora who is collapsing under the strain of her lies; the relationships and trust is collapsing too. The play was again staged differently by director Peter Ashmore who placed rooms mentioned in the stage directions and areas beside the living room and master bedroom in his production. Not everything associated with the play was altered; some characters were representations of real life people. Nora is actually based upon a friend of Ibsen called Laura Kieler. Lauras husband, like Torvald, became ill forcing the couple abroad. Nora arranged a loan with the help of a friend so that her husband did not know anything. Once her husband got better she wrote about her ordeal and tried to sell the story in the form of a novel to pay for the debt. She asked Ibsen for his assistance with this but he wrote back to Laura and advised her to take up the matter with her husband. Ibsen believed that Laura was hiding something from the husband and believed that the husband should take responsibility for her troubles. Laura had not told her husband anything about the loan as she was too scared. When she received the letter from Ibsen saying he would not publish the novel she forged a check to pay back the loan. However, the forgery was discovered and Laura was forced to tell her husband everything. Lauras husband was enraged and filed for separation. As a result, Nora suffered a mental breakdown and had to go to a mental hospital. When she was released from the institution she begged her husband to take her back. I believe that there are obvious parallels here between Nora and Laura

Plants in Production of Recombinant Antibodies

Plants in Production of Recombinant Antibodies Shirin Bagherihanaei A discussion of the techniques, advantages and disadvantages of the use of plants in production of recombinant antibodies for research and therapeutic use with named examples. Introduction   Ã‚   Application of plant for medical proposes goes back to thousand years ago. Our ancestors use plants and extract its beneficial substance to cure different illnesses and relief pain. This idea is continued with us and today we can manipulate the genetic information of plants to make them suitable for the production of recombinant protein and biopharmaceutical medicinal purposes [1]. Since the first generation of recombinant protein from tobacco cell culture, a variety of pharmaceutical products have been introduced such as vaccines, hormones, antibody, growth factors, and cytokines [1,4,9]. However, AB is the most common recombinant protein which is generated by plants and it has been called plantibody. Nowadays the development and the use of transgenic plants for production of recombinant ABs is an attractive subject among scientists because plants are easy to work with and also the cost of the production is considerably low. It is also beneficial because of the large-scale productio n [1]. Production of high quality recombinant protein for research and therapeutic purposes from mammalian are quite expensive, therefore the idea of producing recombinant protein in transgenic animals and plants has formed recently [1]. In this essay, I try to summarise and highlight some of the most cutting-edge techniques in the use of transgenic plants for production of recombinant protein and antibody. I also discuss their advantages and disadvantages with the utilization of plants to produce antibody. Plantibody Plantibody made up of two words: plant and antibody. It means plantibody is an AB that is generated from plants. Antibody is a glycoprotein which mainly made by plasma cells and used by the immune system to neutralize any kind of foreign molecules inside the body such as bacteria and virus. Plantibody has this property to recognize and bind to its specific antigen. It can be generated from tobacco, rice cells culture, Lemna minor (duckweed), Arabidopsis thaliana seeds, Medicago Sativa (alfalfa), lettuce and maize [2] but tobacco is the most common source due to its high leaf biomass yield [3]. According to a report, recombinant protein level in tobacco stem is the same as this level in its leaf. That means to produce recombinant therapeutic protein, the whole plant biomass can be used [3]. Another advantage of tobacco is that it is not edible and this aspect of tobacco reduce biosafety concern but it contains toxic alkaloid and the plant should be purified from the toxic chemicals [3]. As tobacco is not an edible source, regulatory issue for production of recombinant protein is less controversial than food crops such as rice, soy bean and corn. Chinese cabbage has the highest amount of soluble protein among plants. Production Techniques Production of the recombinant protein includes utilizing the whole plant or plant cell culture in vitro [9]. The disadvantages of using the whole plant for production of recombinant AB are: time-consuming generation of transgenic plants, the risk of contamination with fertiliser, unstable quality and yield of the products, applying good manufacturing practice (GMP) to the whole-plant production pipeline [9]. Plant cell suspension culture has the benefits of both mammalian cell culture and whole plants. Undifferentiated plant calli can be developed under a proper condition in the liquid media environment and produce cell suspension culture. Plant cell culture can generate proteins which are more similar to human generated proteins. They can also grow rapidly in a simple media same as bacteria. Plants are eukaryote so they have fairly similar post-transitional modifications such as glycosylation that happen in human cells [9]. Glycosylation is an enzymatic process that glycan adds to o rganic molecules such as lipids and proteins. Correct pattern of protein folding is also essential for recombinant protein to function [1]. It is interesting to note that plant suspension cell culture lack fully functional plasmodesmata, therefore, systemic post-transcriptional gene silencing (PTGS) may be reduced because PTGS is transmitted through plasmodesmata and the vascular system [9]. Generally, three different methods are applied in the production of recombinant AB in plants: Agroinfiltration with recombinant agrobacteria, particle bombardment technology and Infection with modified viral vector [8,14]. The general technique for the production of genetically modified plants is agrobacterium-mediated transformation [2]. Agrobacterium Tumefaciens is a gram negative bacteria which is the cause of crown gall disease in plants [14]. These bacteria live in soil and attract to the plants with wounded parts. However, scientists use this bacteria as a tool for research and therapeutic purposes by introducing the gene with desired properties into the plant cells in plant genetic engineering. The gene of interest can be inserted into Ti plasmid (tumor inducing) then injected into the plants as a host. Plant cell divide out of control and the gene of interest proliferate as well [14]. There is a selectable marker on the T-DNA which is transferred into the host cells therefore it is possible to control if the gene is transferred successfully or not [2]. There are two transformation strategies for generation of recombinant antibody, Stable and transient expression. Stable expression is the stably insertion of cDNA encoding both heavy and light chains of AB into the genome of plants. The gene can be introduced into the chloroplast genome to produce chloroplast transgenic plants which can generate AB with correct folding and disulfide bonds. Some example of the transient expression is agroinfiltration and recombinant plant viruses for the production of antibody [3]. Agroinfiltration system has been used to produce multi-antennary N-glycan that mostly seen in mammalian derived glycoproteins [3]. Transient expressionmethod is fast and convenient for the production of recombinant antibody without generation of transgenic plant. The generation of transient expression is the precondition to stable transformation because it can test expression vectors and protein stability and also it is able to recognize any problem that may have happened [ 8]. Transient expression is better for low scale yield protein production yet transgenic plant are better approach for high yield production and also gives a better expression levels [7]. An important point to note is if the expression is targeted to the endoplasmic reticulum (ER), this results in higher yield [7]. Another approach for the insertion the gene of interest into the plant tissue is particle bombardment technology. The main idea of this technique is some microscopic golden bullet or tungsten bullet covered by the gene of interest. These particles are fired into the plant leaf. This technique used for all type of plants. The golden bullet preferably used because the tungsten bullets have the risk of toxicity for the plants. Then the bullet is placed at the end of plastic bullets and shoot with blasts of air or helium. There is a plastic mesh work shop on the way of the bullets which guide the bullet to move forward. An alternative technique used for this approach which can accelerate the beads with strong electrical discharge which results in a controlled penetration of beads into the plant tissue. After penetration of the DNA dissolved into the cytoplasm of the leaf, the gene of interest can recombine with the chromosome of a plant. Finally, the leaf is transferred to media and let it grow and regenerated using tissue culture [8,11]. This technique does not use a lot due to its high cost and also as this method is physical so the insertion of the gene which is performed by gene gun may cause damage to plant without transferring the genetic material inside the plant and dose not give the precise or desirable results [14]. Production of ab transgenic plants can be generated by viral vectors. However low infectivity with this vectors needs to be considered as an obstacle [2]. One of the disadvantages of viral plant system is the injection of vector to leaf or stem every time which can result in gene mutation during replication of the virus. But we dont face this problem in transgenic stable expression. Therefore, it is extremely important to choose the proper protocol for gene ex pression [3]. Advantages and Disadvantages Plants paly an important role as a bioreactor for production of recombinant protein. Basically, the common systems use for the production of recombinant proteins is the manipulation of mammalian cells, bacterial systems, yeast and etc. However, recently due to some negative aspects of these systems many scientists prefer to work and study plant sources which have those benefits that they are looking for. There are several important benefits with the production of recombinant AB from plants. Firstly, is the large scale of production from cheap raw materials and the reduction of costs in comparison with other techniques of recombinant AB production such as yeast, mammalian and etc. [3,5]. Another advantage of using plants for production of AB is the flexibility of working with plants as it can be used both in vivo and in vitro [3]. In addition, introducing new transgenic plants is possible by sexual crosses and they are quite easy to work with. There is a very low risk of contamination by mammalian viruses when AB is generated from plants [5]. Another advantage is correct folding and assembly of produced AB for both single stranded peptides and multimeric protein with full size. Recombinant protein which generated from edible sources does not require purification. In terms of storage the enzymes which are produced by plants can be formulated to the seeds, so under the suitable condition they can be stored for long period of time and it is also possible to transport them to different locations easily. Plantibody have both avidity and affinity towards its specific antigen and its characteristics maintain the same after purification [1]. Although plants have lots of benefits but it is not 100% perfect source for production of antibody [3]. The most important disadvantage is the fact that Plant N-glycosylation is different from human and mammalian glycosylation. Another negative point is that plants has shown discrete yields due to low gene expression level [7]. There is also the problem with causing allergic and immunogenic reactions in humans, which is because of the difference in glycosylation pattern in humans and plant [7]. Moreover, there are some concerns regarding the activity of proteolytic degradation, which might influence fully assembled IgG that is secreted in the culture media [9]. Production of mycotoxin by impurities, limitation which caused by the environmental condition, and the possibilities of herbicides presence in the product are some other negative aspect of transgenic plants [1]. The controversy about plantibody generation is the presence of gene segments or marker segments in the produced drug and its effect on human body and the probability of allergic reaction to plant glycoprotein [1]. Although there are some disadvantages with the use of transgenic animals such as the risk of contamination of protein with animal viruses and also it takes a long time to produce recombinant protein from transgenic animals but, many biotechnologists prefer to produce AB from mammalian cell lines because the final ABs have a correct glycosylation pattern and protein folding [1]. Plant Antibody Application The extracted AB from plants can be used for many different purposes such as vaccine production, clinical diagnosis protein, pharmaceutical and industrial proteins, biopolymer, biodiesel, food industry, tools for research, and diagnosis tool for chromatography and other immunoassays [1]. The application of AB in research is extremely wide, because of their transferability with the metabolic process in organism [1]. Protein pharmaceutical products are one of the most expensive and important products that human has managed to synthesis them in ways other than natural methods. In recent years, mAB has had an important role in the diagnosis and treatment of cancer-related research [3,12]. Each mAB influence cancer cells in 3 ways: it can signal to the immune system to kill cancerous cells, it can prevent the division of cancer cells or deliver drug to these cells [3]. mAB can attack tumour cells by complement system in cytotoxic reactions through complement system. They bound to the tumor cells which prevent tumor growth and finally result in apoptosis [3]. The ability of AB to prevent the pathogens and tumor cells is due to the affinity of the variable binding sites. This affinity of AB could have enhanced by modifying glycon structure and glycosylation patterns [3]. As we see mAB have many positive aspects for prevention of cancer but their application is not common which is duo to the risk of contamination with human pathogens, high cost and proliferation inability. However, these problems have been eliminated by the production of mAB from other bio-organism like bacteria, yeasts, insects, and plants [3]. The monoclonal AB expressed in plants by tobacco mosaic viru s vectors [3]. Nimotozomab is a humanized anti-epidermal growth factor receptor recombinant AB which is produced in animal cell culture. This AB is used for treatment of different carcinoma cells. It seems that a mutation in the N297 position in the IgG1 FC region of this AB and apply it in a transgenic plant which result in producing a form of nomotozomab that is similar to mammalian-cell-produced AB. It also has the property to block the EGFR interaction and have antitumor effects [5,7]. Nicotiana tabacum were transformed by A.tumefaction-mediated gene transfer method. In order to infect the plant cells, recombinant pDEGF-R Agbacterium bearing the binary vector was applied [5,7]. According to experiments the mAB which was generated in plants was as effective as the one which was generated in mammalian (nude mice). In another experiment marine, mAB could prevent Brest cancer cell growth and mAB was generated from transgenic tobacco plant which had the same function as the murine mAB. Therefore, pl ants such as tobacco can produce two different mAB which can target two different types of cancer cells [3]. The most frequently chosen host cell lines used for recombinant protein expression are Tobacco BY-2 (Bright yellow-2) and NT-1 (Nicotiana tabacum-1) cells [9]. Generally, IgA, IgG and IgM are generated from plants. IgA and IgM have the potential for commercial production. They attach antigens in the first line defence at gastrointestinal mucosal surface, tears, saliva and milk [14]. IgG and IgA have been introduced in Nicotiana, Arabidopsis. Plantibody have a high level of safety which rise the interest for production of mAB from plant Examples include the Guys 13 IgG1 (Fischer et al., 1999b; Sharp and Doran, 2001a, 2001b), a human mAB against hepatitis B virus surface antigen (HBsAg) (Yano et al., 2004), a human anti-rabies virus mAB (Girard et al., 2006), and most recently a human anti-HIV mAB (Holland et al., 2010) all of which have been reported to be expressed in tobacco cell suspension cultures [9]. Lots of effort have been done for production of these ABs in large scale but none of them sell in the market due to the high cost. Nonetheless, two plantibody is used in clinical CAROX which was expressed in transgenic tobacco that takes part in the prevention of tooth decay and the second one have an effect against non-Hodgkin-lymphoma(NHL) [2]. The following table demonstrates some IgA plantibodies which are generated in recent research. Plantibody Source Target Plantibody Characteristic sIgA/G Transgenic Tobacco Plant S. Mutans Prevention of tooth decay Human IgA Maize Herpes Simplex Virus and saga 1 antigen Herpes disease and sperm agglutination Coccidia specific chicken IgA Nocotiana Benthamiana Eimeria Acervulina Against the coccidiosis Virus-specific IgA Tomato and Nocotiana Benthamiana Rota Virus Development for passive immunisation against Diarrhoeal disease Chimeric Enterotoxigenic Bacteria-Specific IgA (VHH-IgA) Arabidopsis Thaliana seeds Enterotoxigenic Escherichia Coli (ETEC) Passive Mucosal Immunisation Against Enteric Infections Chimeric Toxic-Specific IgA (Hybrid IgG/IgA) A. Thaliana Shiga Toxin From ETEC Against Haemorrhagic colitis and Hemolytic-uremic Syndrome Monomeric IgA1 K! Variants (Infliximab, Adalimumab, Ustekinumab) N. Benthamiana Against Autoimmune disease 2G12 sIgA N. Benthamiana Human Immunodeficiency Virus Anti-HIV Human This table shows IgA plantibodies, their sources, targets and characteristics. Conclusion and future perspectives Although there are problems with the generation of plantibody from mammalian cells, but they are the most common source for production of mABs. This is due to the correct folding and similar glycosylation patterns to human, complex type N-glycosyl, moieties and the presence of polypeptides with disulfide bonds. Using recombinant antibody fragment in research therapeutic purposes, biotechnology and pharmaceutical science is increasing because of the intrinsic properties of the components such as the ability to penetrate better and detect antigen with higher affinity, small size and easy production compared to AB full size [6,13]. More powerful tissue or inducible promoters, enhancement of transcript stability, translational improvement with cutting edge sequences or strategies and transgenic chloroplast system are some ways which are studied in order to raise the AB expression level in plants in the future [8]. Drug production seems to be one of the promising field in terms of commerc ial development in biotechnology [1]. In total, we can see a promising future for the production of drugs, vaccine, recombinant protein and biopharmaceuticals from plants. However, several bottlenecks including regulatory guidelines, ethical issues and public approval must be taken into account and solved [1]. References: Hashemzadeh, H. and Zebarjadi, A. (2014). Application of transgenic plants as factories for producing biopharmaceutical. [online] www.researchgate.net. Available at: https://www.researchgate.net/publication/268514150_Application_of_transgenic_plants_as_factories_for_producing_biopharmaceutical?enrichId=rgreq-4465fb2b3b0479dec4752b8195daab6c-XXXenrichSource=Y292ZXJQYWdlOzI2ODUxNDE1MDtBUzoxNjU2NDA4MDM0NjMxNjhAMTQxNjUwMzI1MzMxOA%3D%3Del=1_x_3_esc=publicationCoverPdf [Accessed 17 Mar. 2017]. Frenzel, A., Hust, M. and Schirrmann, T. (2013). Expression of Recombinant Antibodies. [online] journal.frontiersin.org. Available at: http://journal.frontiersin.org/article/10.3389/fimmu.2013.00217/full [Accessed 17 Mar. 2017]. Moussavou, G., Ko, K., Lee, J. and Choo, Y. (2015). Production of Monoclonal Antibodies in Plants for Cancer Immunotherapy. [online] Hindawi.com. Available at: https://www.hindawi.com/journals/bmri/2015/306164/ [Accessed 17 Mar. 2017]. Valdà ©s, R., Padilla, S., Gà ³mez, L. and Borroto, C. (2003). Large-scale purification of an antibody directed against hepatitis B surface antigen from transgenic tobacco plants. [online] www.researchgate.net. Available at: https://www.researchgate.net/publication/10635451_Large-scale_purification_of_an_antibody_directed_against_hepatitis_B_surface_antigen_from_transgenic_tobacco_plants?enrichId=rgreq-9f9d9c1d7e1ac5013b459ed8c8d81938-XXXenrichSource=Y292ZXJQYWdlOzEwNjM1NDUxO0FTOjk4OTYxOTIyNzIzODQ1QDE0MDA2MDU3NjkyNjc%3Del=1_x_3_esc=publicationCoverPdf [Accessed 17 Mar. 2017]. Pujol, M. and Gavilondo, J. (2013). Transgenic plants of Nicotiana tabacum L. express aglycosylated monoclonal antibody with antitumor activity. [online] www.researchgate.net. Available at: https://www.researchgate.net/publication/263802548_Transgenic_plants_of_Nicotiana_tabacum_L_express_aglycosylated_monoclonal_antibody_with_antitumor_activity?enrichId=rgreq-e820e9544359d3a71edb5ce55845f43a-XXXenrichSource=Y292ZXJQYWdlOzI2MzgwMjU0ODtBUzoxMTczNzkwNTI4NzE2ODFAMTQwNDk5Njc1NTQwMg%3D%3Del=1_x_3_esc=publicationCoverPdf [Accessed 17 Mar. 2017]. Hayes C. Generation and Application of Recombinant Antibody Fragments for Prostate Cancer Detection. A thesis submitted for the degree of Ph.D. School of Biotechnology, Dublin City University,Dublin 9,Ireland 2010 j6) Rodrà ­guez, M., Pà ©rez, L., Gavilondo, J., Garrido, G., Bequet-Romero, M., Hernà ¡ndez, I., Huerta, V., Cabrera, G., Pà ©rez, M., Ramos, O., Leyva, R., Leà ³n, M., Ramos, P., Triguero, A., Hernà ¡ndez, A., Sà ¡nchez, B., Ayala, M., Soto, J., Gonzà ¡lez, E., Mendoza, O., Tiel, K. and Pujol, M. (2012). Comparative in vitro and experimental in vivo studies of the anti-epidermal growth factor receptor antibody nimotuzumab and its aglycosylated form produced in transgenic tobacco plants. [online] http://onlinelibrary.wiley.com. Available at: http://onlinelibrary.wiley.com/doi/10.1111/pbi.12006/full [Accessed 17 Mar. 2017]. 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Expert Opin on Biolog Ther 2003 Apr;3(2):305-18. Hayes C. Generation and Application of Recombinant Antibody Fragments for Prostate Cancer Detection. A thesis submitted for the degree of Ph.D. School of Biotechnology, Dublin City University, Dublin 9, Ireland 2010. Gà ³mez, L., Valdà ©s, R., Pujol, M. and Brito, J. (2011). Kinetic of Expression of a Plantibody in (Nicotiana tabacum) Plants Cultivated in Different Substrates (Zeolite and Soil). [online] www.researchgate.net. Available at: https://www.researchgate.net/publication/287551483_Kinetic_of_Expression_of_a_Plantibody_in_Nicotiana_tabacum_Plants_Cultivated_in_Different_Substrates_Zeolite_and_Soil [Accessed 17 Mar. 2017]. Vasilev, N. (2015). Developments in the production of mucosal antibodies in plants. [online] Sciencedirect.com. Available at: http://www.sciencedirect.com/science/article/pii/S0734975015300525 [Accessed 17 Mar. 2017].

Middlemarch by George Eliot and Jude the Obscure by Thomas Hardy Essay

Middlemarch by George Eliot and Jude the Obscure by Thomas Hardy The Victorian era brought about many changes throughout Great Britain. Man was searching for new avenues of enlightenment. The quest for knowledge and understanding became an acceptable practice throughout much of the scientific community. It was becoming accepted, and in many ways expected, for people to search for knowledge. Philosophy, the search for truth, was becoming a more intricate part of educating ones self; no longer were people holding on to old-fashioned ideas. Central to the story lines of Middlemarch, written by George Eliot, and Jude the Obscure, by Thomas Hardy, is the theme of ambition and the tempering of expectations both to social difficulties, and on a broader scale, human frailty. Dorthea Brooke and Sue Brideshead display elements of the â€Å"new woman† and both are driven to accomplish what each desires. Both are intelligent and educated women. The contrast in the two comes from the different motives each has to separate themselves from the norm. Sue is self-centered in her â€Å"independence,† while Dorthea is an ardent spokeswoman for social reform and justice. Both women follow different paths, neither ending up at a position they once knew they would attain. Dorthea is depicted early in the novel as having an intimidating presence; however, at a dinner with the supposedly learned and intelligent Mr. Casaubon, she feels quite uneasy. He is an older man with an unattractive appearance which goes completely unnoti ced to the â€Å"lovestruck† Dorthea. Her sister Celia comments, â€Å"How very ugly Mr. Casaubon is!† Dorthea responds by comparing him to a portrait of Locke and says he is a â€Å"distinguished looking gentleman.† Later, after dinner, Casaubon and Dorthea discuss religious matters and she looks at him in awe because of his supposed superior intellect. â€Å"Here was a man who could understand the higher inward life†¦a man who’s learning almost amounted to proof of whatever he believed!†(p. 24). As intelligent as Dorthea is, she failed to see Casaubon for the man he really is, and will be, in marriage. Casaubon proposes to her and she accepts. She sees this as an opportunity to further advance her own intellectual abilities and help a great man complete his studies. Later she would realize her husband has very limited intellectual abilities and is not a suitable companion for... ... the money, even though she should be entitled to it. She was always faithful do Casaubon, despite not loving him. They marry and have two children with a â€Å"house full of love.† Will does become a member of Parliament, but he never makes a fortune. Dorthea lives a happy life because she followed her independence. She made choices she regretted, but overcame them with her strong personality. She never accomplished all the goals she had set out to, but she did find love with Will. The money she gave up could have helped her establish the knowledge and training she wanted to achieve, but her love of Will was more important to her than her academic endeavors. She was indeed an independent woman with a strong sense of moral values. Sue was the exact opposite of her. Sue never wished to help anyone but herself. She did whatever made her happy or secure. Her independent nature came from her own self-absorbed sense of life. She never really loved Jude, or anyone else. She just enjoyed the idea of someone loving her. She was dependent on this in order for her to feel a sense of belonging. Both women followed patterns of being a â€Å"new woman,† but neither one followed the pattern completely.

Yersinia pestis :: Biology Biological Health Medical Essays

Yersinia pestis Life History Yersinia pestis is the causative agent of the systemic invasive infectious disease often referred to as the plague. The Y. pestis is an extremely virulent pathogen that is likely to cause severe illness and death upon infection unless antibiotics are administered. In the past, Y. pestis has caused devastating epidemics during three periods of modern history; the Justinian Plague spread from the Middle East to the Mediterranean during the 6th-8th centuries AD and killed approximately 25% of the population below the Alps region. Perhaps the most famous incidence of any disease was the devastating Black Plague of 8th-14th century Europe that eradicated 25 million people (nearly 25% of the population) and marked the end of the Dark Ages. The third endemic began in 1855 in China and was responsible for millions of deaths. Microbiological Characteristics Yersinia pestis is a Gram-negative, bipolar-staining coccobacillus member of the Enterobacteriaceae family, and is an obligate intracellular pathogen that must be contained within the blood to survive. It is also a fermentative, motile organism that produces a thick anti-phagocytic slime layer in its path. Transmission Y. pestis has the ability to cause disease in rodents, insects and humans. The primary carriers of the pathogen are the Oriental rat flea, Xenopsylla cheopis, and infected rodents. The path of transmission to humans usually involves a flea feeding on an infected rodent and becoming a carrier of infection. Once internalized, the bacteria will continue to reproduce until a large blockage is formed in the midgut of the flea, causing digestion and other gastrointestinal functions to cease. When the flea attempts to feed on humans, the blockage inhibits any blood from entering the stomach cavity; instead, portions of the blockage, often containing 11,000-24,000 bacilli, are regurgitated into the mammalian host. Virulence Factors Yersinia pestis encodes two antigenic molecules: Fraction 1 (F1) capsular antigen, and VW antigen. Both of these molecules are needed for pathogenicity, and are not expressed at temperatures lower than 37Â °C. This requirement is the main reason why Yersinia is not virulent in fleas, since their body temperature normally levels around 25Â °C. Yersinia is a model for studying Type III Secretion Systems (TTSS) that inject bacterial proteins into a host cell. In Y. pestis, it is the translocation of Yersinia outer proteins (Yop’s) that blocks the host cell’s ability to communicate with immune system cells and down-regulates the response of phagocytic host cells to infection.

Rank of Icici Stock Minds

Sheet1 RANK 1 2 3 4 PARTICIPANT NAME COLLEGE NITIN GAJANAN MALUSARE JANARDAN INSTITUTE GIRISH MAHESHKUMAR SAVLANI K S BUSINESS SCHOOL PRATEEK GOVILA BIT MESRA PUNE UNIVERSITY DEPARTMENT OF KISHAN BHATTAD MANAGEMENT SCIENCES (PUMBA) CITY MUMBAI AHMEDABAD RANCHI PUNE PORTFOLIO 1666999. 9 1666553. 6 1666432. 5 1662356. 05 TURNOVER 16935103. 38 19998020 19946293. 4 0 % GAIN 11. 13% 5. 67% 9. 36% 0. 00% Basis highest % change in profit compared to the previous day portfolio COMMENTS REMARKS 6 7 8 9 10 11 12 13 14 15 16 JIGAR B SHAH SHANTI BUSINESS SCHOOL INDIAN INSTITUTE OF MANAGEMENT SAGAR CHOUDHURY (IIM) ISHAN ONKAR TRIVEDI NIRMA INSTITUTE OF MANAGEMENT ANIL KUMAR YADAV IMS GHAZIABAD RAVINDER REDDY IIT – MADRAS (MGMT DEPT) JAY PRAKASH MEHTA KANDIVALI EDUCATION SOCIETYÂ   INDIAN INSTITIUTE OF PARV DHIMAN MANAGEMENT(IIM) LALA LAJPATRAI INSTITUTE OF DHIRAJ KUNDANMAL SONI MANAGEMENT KALPESH RAJPUT B. 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DALMIYA COLLEGE MUMBAI VISHWA VISHWANI SCHOOL OF PREM KUMAR HYDERABAD BUSINESS PRARTHANA CHANDAR UNITED WORLD SCHOOL OF AMIN BUSINESS MUMBAI SYMBIOSIS COLLEGE OF ARTS & GEORGE PARAPUZHA JOB COMMERCE PUNE LALSINGH SANGRAMSINGH S. B PATIL INSTITUTE OF RAJPUT PUNE MANAGEMENT SUDEEPTA SARMA IILM INSTITUTE FOR HIGHER BORUAH DELHI EDUCATION (IILM ) INSTITUTE OF MANAGEMENT DEVELOPMENT AND RESEARCH (IMDR) AGNEL CHARITIES AGNEL SEVA SANGHA'S FR. C. RODRIGUES INST. OF MANAGEMENT. STUDIES RUSTOMEJEE BUSINESS SCHOOL DAYANANDA SAGAR ACEDEMY OF TECHNOLOGY AND MANAGEMENT MUMBAI INSTITUTE OF MANAGEMENT & RESEARCH GURU NANAK INSTITUTE OF MANAGEMENT STUDIES (GNIMS) INDIAN INSTITUTE OF KNOWLEDGE MANAGEMENT (IIKM) AMITY GLOBAL BUSINESS SCHOOL ACCURATE BUSINESS SCHOOL ATHARVA SCHOOL OF BUSINESS NSTITUTEÂ   OF TECHNOLOGY AND MANAGEMENT- INSTITUTE OF FINANCIAL MARKETS (ITM-IFM) RAWAL INSTITUTE OF ENGINEERING & MANAGEMENT KIRLOSKAR INSTITUTE OF ADVANCED MANAGEMENT STUDIES CITY COLLEGE INDIAN INSTITUTE OF TECHNOLOGY PARUL INSTITUTE OF MANAGEMENT INDIAN INSTITIUT OF MANAGEMENT(IIM) MEENAKSHI SUNDARAJAN SCHOOL OF MGMT JAIPURIA INSTITUTE OF MANAGEMENT STUDIES H. 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GAUR HARI SINGHANIA INSTITUTE PUSHPINDER SINGH PURI OF MANAGEMENT & RESEARCH INDIAN INSTITUTE OF MANAGEMENT SASIKANTH BAPATLA (IIM) ABHISHEK MADASSERY FEDERAL INSTITUTE OF SCIENCE & ASHOK TECHNOLOGY(FISAT) RIZVI INSTITUTE OF MANAGEMENT KARAN KIRTI DOSHI STUDIES R. A.PODAR INSTITUTE OF AKSHIT BAJ MANAGEMENT ACHARYA'S BANGALORE BUSINESS SURI SAI SRIKANTH SCHOOL INDIAN INSTITUTE OF PLANNING AND VIREN PARMAR MANAGEMENT(IIPM) SREE NARAYAN GURUKULAM SHAHANAS PA COL LEGE OF ENGINEERING FABEESH MOHAMED IIPM, KOCHI G SANDEEP GANDHIKOTA BUSINESS SCHOOL DEEPAK HEDDA GARDEN CITY COLLEGE KOLHAPUR INSTITUTE OF VENUGOPAL LALIT DAVDA TECHNOLOGY INSTITUTE OF BUSINESS AND SAISMITA DALAI COMPUTER STUDIES(IBCS ) SOUMITRA KUMAR INDIAN INSTITUTE OF PLANNING & MANDAL MANAGEMENT(IIPM) DIPTI DINESH NADKARNI IEIBS AKADEMIA BLESSINA JEBARAJ JEPPIAR ENGINEER COLLEGE SYMBIOSIS INSTITUTE OF BUSINESS STUTI BANSAL MANAGEMENT (SIBM) INDIAN INSTITUTE OF PLANNING & P SUNIL KUMAR MANAGEMENT(IIPM) JAYAMUKHI INSTITUTE OF GOUTHAM BIJJALA TECHNOLOGICAL SCIENCES DEBASISH BAJ ITM BUSINESS SCHOOL ORIENTAL INSTITUTE OF ANIRUDH MAHESH SANGHI MANAGEMENT VIVEK AGARWALA LOVELY PROFESSIONAL UNIVERSITY VELS INSTITUTE OF BUSINESS DASARATHY GANESAN ADMINISTRATION GANESH R NIT DEEPMALA YADAV 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 LUCKNOW MUMBAI AHMEDABAD DELHI BANGAL ORE KOLKATA AHMEDABAD CHENNAI PUNE HYDERABAD MUMBAI KOLKATA HYDERABAD AHMEDABAD DELHI BANGALORE AHMEDABAD KANPUR KOZHIKODE KOCHI MUMBAI JAIPUR BANGALORE PUNE KOCHI KOCHI HYDERABAD BANGALORE KOLHAPUR BHUBANESHWAR BHUBANESHWAR MUMBAI CHENNAI PUNE HYDERABAD WARANGAL WARANGAL MUMBAI JALANDHAR CHENNAI TRICHY 1500416. 1500306. 63 1500152. 85 1500148 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 Page 2 0 4957494. 14 461163. 8 1164534 0. 04% 0. 75% 0. 01% 0. 59% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00%Sheet1 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 PREEYAM HIMANSHU TOLIA GOURAV TYAGI INDRAJEET SARKAR MEVISH PANCHAL PIYUSH MANOJ MODHSARAF CHANDNI JITENDRABHAI ZAVERI ABHYUDAY SINGH CHAUHAN FAIZAN KHAN KARTHIK HARIHARAN PRADEEP V SATENDER SINGH RAWAT PRAMOD AGRAWAL HARSH RANJAN ANIRBAN TARUN HAZRA KUNWAR VIKRAM SINGH BHAVIK JAGDISHBHAI BHAVSAR RAHUL VIJAYAKUMAR PRATIK MAHENDRA MANANI BHAGYASHREE SURESH PATIL SAINATH NIVLAKAR VISHAL SINGH JOHNSON BANDI ANKIT ANAND SHUBHAM JAIN ANUBHAV SINGH PADALIYA DHAVAL DEEPCHAND RADHYASHYAM GUPTA AMRITA MAZUMDAR YOGESH HARSHADBHAI PATEL SUJIT P ANUTOSH KUMAR AJEET PRATAP KHANDE NIKET CHANDAK SATYAJIT MAHAPATRO MANJUNATH RA SHREY ARORA GAURAV KAMBLE JOYDEEP DEY PANKAJ RAMESH RAI SURAJ SANJAY TAMHANE RADHE NARAYANDAS RATHI PRANAY VIJETA MUKESHKUMAR GUPTA KISHANKUMAR CHAUDHARY RAJENDER AGGARWAL SAMBHAV GUPTA RA JIV TARASHANKAR MAURYA PATHIK ASHOK DOSHI SACHIN DADABHAU ARGADE NIKUNJKUMAR BIPINCHANDRA GOR ARVIND SINGH NABA KUMAR MEDHI AFSAR TANWEER VIVA COLLEGE OF ARTS,COMMERCE AND SCIENCE ITS GHAZIABAD INSTITUTE OF ENGINEERING & MANAGEMENT BHARTIVIDYAPEETH COLLEGE OF MANAGEMENT ALKESH DINESH MODI IMS MUMBAI GHAZIABAD KOLKATA MUMBAI MUMBAI 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1500000 1499980. 58 1499898. 8 1499840. 31 1499298. 49 1499240 1498978. 6 1498975. 44 1498765. 1 1498463. 91 1498376. 77 1497879. 7 1497736 1497537. 85 1497026. 1 1496824. 5 1496650 1496525. 13 1496018. 95 1495073. 73 1493679. 6 1491854. 05 1490459 1489680 1487377. 61 1485605. 25 1484849 1483542. 5 1481977. 63 1480659. 65 1480337. 56 1480059. 8 1478627. 88 1478035. 91 1477020. 08 1476154. 24 1475551. 17 1474566. 66 1458569. 63 1455800 1450658. 24 1444595 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 00% 0. 48% -0. 01% 0. 13% -0. 05% 1. 24% 0. 00% 0. 18% 0. 08% -0. 11% 0. 54% 0. 54% 0. 68% 0. 00% 0. 50% -0. 23% 0. 73% -0. 27% 0. 16% 0. 7% -0. 04% -0. 35% 0. 13% 0. 88% -0. 38% 0. 14% 0. 12% 0. 77% -2. 62% -1. 70% 0. 95% 0. 69% 0. 23% 2. 83% -0. 67% -4. 74% -0. 41% 1. 31% -2. 50% -3. 29% -3. 72% RAJKOT R K UNIVERSITY DHARMSINGH DESAI INSTITUTE OF TECHNOLOGY & MANAGEMENT(DDIT) NADIAD NARSEEMONJI INSTITUTE OF MUMBAI MANAGEMENT STUDIES (NMIMS) INDIAN INSTITIUT OF INDORE MANAGEMENT(IIM ) VELLORE INSTITUTE OF CHENNAI MANAGEMENT (VIT) GLA UNIVERSITY II MATHURA GLA UNIVERSITY I MATHURA JAIPUR GYANVIHAR INSTITUTE DY PATIL INSTITUTE OF MANAGEMENT MUMBAI BELAPUR SWAMI VIVEKANAND INSTITUTE OF MUMBAI MANAGEMENT STUDIES CHIMANBHAI INSTITUTE OF AHMEDABAD MANAGEMENT CRESENT BUSINESS SCHOOL (B. S.ABDUR RAHMAN UNIVERSITY) CHENNAI ICFAI BUSINESS SCHOOL SANJAY GHODAWAT INSTITUTE ENTREPRENEURSHIP DEVELOPMENT INSTITUTE OF INDIA (EDI) JAIPURIA INSTITUTE OF MANAGEMENT NATIONAL INSTITUTE OF TECHNOLOGY(NIT) SCHOOL OF MANAGEMENT, KIIT UNIVERSITY INTERNATIONAL SCHOOL OF INFOMATICS & MANAGEMENT (IIIM ) TRINITY INSTITUTE OF PROFESSIONAL STUDIES NEW DELHI INSTITUTE OF MANAGEMENT (NDIM) GAHLOT INSTITUTE HERITAGE GROUP OF INSTITUTIONS GANPAT UNIVERSITY XAVIER INSTITUTE OF MANAGEMENT BIFM SOCIETY FOR EDUCATION & RESEARCH LYYOD INSTITUTE OF MANAGEMENT INDIRA COLLEGE FACULTY OF MANAGEMENT STUDIES (FMS) MS RAMAIAH COLLEGE INSTITUTE OF RURAL MANAGEMENT(IRM) ADITYA COLLEGE NSHM BUSINESS SCHOOL(NBS) UNITED BUSINESS SCHOOL SIES COLLEGE OF MANAGEMENT, NERUL D Y PATIL GREATER NOIDA INSTITUTE OF TECHNOLOGY GNVS INSTITUTE OF MANAGEMENT S V INSTITUTE OF MANAGEMENT INDIAN INSTITUTE OF MANAGEMENT(IIM) LUCKNOW AMITY BUSINESS SCHOOL DR. G D POL FOUNDATION YMT COLLEGE OF MANAGEMENT FLAME BUSINESS SCHOOL MUMBAI KOLHAPUR AHMEDABAD JAIPUR WARANGALBHUBANESHWAR JAIPUR DELHI DELHI MUMBAI KOLKATA AHMEDABAD BHUBANESHWAR DELHI DELHI PUNE DELHI BANGALORE JAIPUR MUMBAI DURGAPUR AHMEDABAD MUMBAI PUNE DELHI MUMBAI KADI DELHI AHMEDABAD MUMBAI PUNE 14 0773. 02 0 469778. 52 5920537. 72 278734. 9 1516500 0 1806549. 85 603598. 3 3727765. 43 9780 0 1359144. 05 0 427764 0 4693020. 75 4546906. 55 293725 148376. 1 2361056. 9 0 0 6257722. 15 0 0 664855. 8 24198 15104297. 55 14073842. 49 6103274. 4 10377288. 23 14504753. 51 7697288. 85 1796680. 35 19766905. 12 1469829. 15 6301258. 4 0 1486542. 2 15548000 MODERN COLLEGE PUNE NARSEEMONJI INSTITUTE OF MANAGEMENT STUDIES HYDERABAD LOVELY PROFESSIONAL UNIVERSITY JALANDHAR INDIAN INSTITUTE OF FOREIGN TRADE KOLKATA – IIFT XISS- XAVIER INSTITUTE OF SOCIAL SCIENCE RANCHI SMT.HIRABEN NANAVATI INSTITUTE OF MANAGEMENT & RESEARCH FOR WOMEN AMRITA SCHOOL OF BUSINESS SANKLP BZ COLLEGE INDIAN INSTITIUT OF MANAGEMENT(IIM) JAGANNATH INSTITUTE OF MANAGEMENT STUDIES (JIMS) VIVA COLLEGE OF MANAGEMENT JAMNALAL BAJAJ INSTITUTE OF MANAGEMENT STUDIES RAJAGIRI SCHOOL OF MANAGEMENT ST FRANCIS INSTITUTE OF MANAGEMENT MODERN INSTITUTE OF BUSINESS MANAGEMENT JAIPUR ENGINEERING COLLEGE & RESEARCH CENTRE (JECRC) SYDENHAM INSTITUTE OF MANAGEMENT STUDIES 200 201 202 203 204 205 206 207 208 NEHA ANIL SONAWANE ASHIS KUMAR NAYAK ANKUR HANUMANDASJI LOYA RAMAKRISHNA REDDY PV ASHISH VATS NILESH KALOJI PATIL CHAITANYA GANDHI ASHISH M THOMAS SAVIO IGNATIUS PEREIRA PUNE COIMBATORE PUNE BANGALORE DELHI MUMBAI MUMBAI KOCHI MUMBAI 1443019. 28 1438403. 49 1421968. 3 1403592. 6 1387933. 23 1382846. 1 1347535. 19 1315017. 23 1232887. 18 7221815. 06 6706791. 4 7983803. 6 15200000 17918166. 91 15326224 18887715. 9 14959391. 89 18177223. 5 -3. 67% -3. 27% -1. 88% -3. 44% -9. 27% -11. 30% -13. 48% -13. 75% -12. 7% Disqualified as Turnover exceeded 2 crore on 13-Mar2013 Disqualified as Turnover exceeded 2 crore on 13-Mar2013 Disqualified as Turnover exceeded 2 crore on 13-Mar2013 Disqualified as Turnover exceeded 2 crore on 14-Mar2013 Disqualified as Turnover exceeded 2 crore on 13-Mar2013 Disqualified as Turnover exceeded 2 crore on 13-Mar2013 Disqualified as Turnover exceeded 2 crore on 14-Mar2013 Disqualified NEHAL MEHUL DOSHI PUNE 2158899. 67 681523032. 99 30. 27% Disqualified INDU RAJ SHARMA JAIPUR 1746172. 62 136730223. 38 3. 01% Disqualified PARIN JAYESH JAIN MUMBAI 1689359. 21 29836586. 33 5. 38% Disqualified MRINAL AGRAWAL ICFAI BUSINESS SCHOOL GURGAON 1652256. 13 1019418. 73 9. 76% Disqualified DIPEN GIRISHBHAI DESAI SJPIM AHMEDABAD 1638720. 53 38609002. 49 5. 92% Disqualified KRATIKA KAPOOR BANASTHALI VIDYAPITH CAMPUS BANASTHALI 1602585. 74 174113219. 86 4. 03% Disqualified AKASH SINGHAL IILM DELHI DELHI 1595289. 76 Page 3 20201491. 1 0. 81% Sheet1 LAL BAHADUR SHASTRI INSTITUTE OF MANAGEMENT DELHI Disqualified as Turnover exceeded 2 crore on 14-Mar2013 Disqualified as Turnover exceeded 2 crore on 13-Mar2013 Disqualified as Turnover exceeded 2 crore on 13-Mar2013 Disqualified as Turnover exceeded 2 crore on 13-Mar2013 Disqualified as Turnover exceeded 2 crore on 13-Mar2013 Disqualified as Turnover exceeded 2 rore on 13-Mar2013 Disqualified as Turnover exceeded 2 crore on 14-Mar20 13 Disqualified as Turnover exceeded 2 crore on 13-Mar2013 Disqualified as Turnover exceeded 2 crore on 13-Mar2013 Disqualified as Turnover exceeded 2 crore on 13-Mar2013 Disqualified as Turnover exceeded 2 crore on 13-Mar2013 Disqualified SURBHI BEGWANI 1579115. 33 20629835. 15 2. 46% Disqualified HIMANSHU SHEKHAR BIT MESRA KOLKATA 1548771. 65 85329123. 21 -3. 35% Disqualified SANDEEP KUMAR INDIAN INSTITUTE OF FOREIGN TRADE DELHI (IIFT) 1513222. 8 44599450. 3 8. 38% Disqualified RAHUL SHYAMKUMAR JAIN ICFAI BUSINESS SCHOOL PUNE 1508190. 05 61504026. 95 -6. 39% Disqualified ARUN K IIT – MADRAS ENGG. DEPTCHENNAI 1501859. 94 57156690. 7 -2. 77% Disqualified DEEPANKAR KSHITIZ EMPI BUSINESS SCHOOL NALANDA INSTITUTE OF ADVANCED STUDIES DELHI 1497135. 03 69303860. 97 -2. 90% Disqualified SHEIKH HOSSAIN KOLKATA 1477135. 35 24163113. 25 -1. 52% Disqualified KUNTAL DEVESH DAVE SAL INSTITUTE OF MANAGEMENT AHMEDABAD 1447490 29854052. 5 -6. 76% Disqualified GOBIN RANA SONA COLLEGE OF MANA GMENT INSTITUTE OF MANAGEMENT & TECHNOLOGY(IMT) SALEM 1444626. 85 37832292. 25 -1. 46% Disqualified TUSHAR SHARMA MANMOHAN SINGH SIKARWAR GHAZIABAD 1380792. 05 40439282. 21 -3. 78% Disqualified ICFAI BUSINESS SCHOO L(IBS) AHMEDABAD 1064207. 96 111815542. 74 -21. 15% Page 4